P80 - An evaluation of the efficacy and safety of a dust mite sublingual immunotherapy in allergic asthmatic children: a retrospective clinical data analysis over a three-year period

Methods This study has followed a retrospective clinical and laboratory data analysis. The data were classified according to the treatment protocol given into two groups, both of which continued their treatment plan for a period of three years. Fifty children (Control group) who were treated with combination therapy (budesonide 80 mg /formoterol 4 mcg), two puffs twice daily. The Control group compared to fifty children (SLIT group) who were treated with the same combination therapy plus standardised extract 50/50 Dp / Df, a dust mite SLIT. The data analyses were conducted at baseline and after three years in each and in between groups. Results The results of this study showed that SLIT group has a highly statistically significant reduction in the use of daily doses of the combination treatment (budesonide / formoterol) (p<0.0001), in comparison to control group (p=0.397). In addition, in the SLIT group there were 97% of the patients totally stopped both control and reliever medications in the final six months and only continued with SLIT. Moreover, there were more improvements in FVC and FEV1 in SLIT compared to control group. Additionally, these results revealed that SLIT significantly reduced the clinical outcome scores. There were no systematic (anaphylaxis) side effects reported with SLIT.